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学术报告:Multivalent binding and selectivity in cell targeting, molecular recognition and receptor activation

日期: 2017-11-09     阅读次数:13

报告题目:Multivalent binding and selectivity in cell targeting, molecular recognition and receptor activation

报 告 人:Jure Dobnikar, Chinese Academy of Sciences, University of Cambridge

报告时间:1113日上午940

报告地点:物理科技楼245

报告摘要:One of the key challenges in nano-science is to design nanoparticles that can recognize and target specific objects. One such example are ligand-coated nanoparticles binding to surfaces covered with receptors forming bonds with the ligands. The requirement of many applications is that the particles bind selectively to surfaces with receptors either above a threshold concentration or in a specific geometric arrangement. Such nanoparticles would enable precise functioning of nano machines, as well as selective targeting of cells in drug delivery. Similarly, many biological processes rely on chemical activation based on (macro-) molecular recognition. Also in this case, the receptors need to selectively bind to specific molecules to get activated. In recent years, it has been shown that "super-selectivity" can only be achieved with multiple weak reversible bonds where many ligands simultaneously bind to the surface receptors. Only in such systems, the fraction of bound particles varies sharply with the receptor concentration and nano-particles can be designed such that they approach the on-off binding behaviour required for super-selective targeting. I will report on our recent work on physics of multivalent binding and specifically address targeting cancer cells, molecular recognition and multivalent receptor activation by DNA-peptide complexes in the immune system.

Publications:

[1] N.W. Schmidt, F. Jin, R. Lande, T. Curk, W. Xian, L. Frasca, D. Frenkel, J. Dobnikar, M. Gilliet, G.C.L. Wong, Antimicrobial-peptide-DNA complexes amplify TLR9 activation via liquid-crystalline ordering, Nature Materials 14, 696 (2015)

[2] T. Curk, J. Dobnikar, D. Frenkel, Rational design of molecularly imprinted polymers, Soft Matter 12, 35 (2016)

[3] T. Curk, J. Dobnikar, and D. Frenkel, Optimal multivalent targeting of mem-

branes with many distinct receptors, PNAS 114 7210 (2017)

报告人简介:

EDUCATION AND HABILITATION

10.1996  B.Sc. degree in Physics at University of Ljubljana, Slovenia

03.2001  PhD degree in Physics at University of Ljubljana, Slovenia

11.2002  Assistant Professor, University of Maribor, Slovenia

09.2010  Associate Professor, University of Maribor, Slovenia

06.2014  Professor of Soft Matter, Beijing University of Chemical Technology, China

06.2016  Professor of Physics, , Beijing, China

PROFESSIONAL EXPERIENCE

1996-2000  PhD student: CAMTP, Univ. Maribor & J. Stefan Institute, Ljubljana, Slovenia

2001-2004  Post doctoral fellow: Faculty of Physics, University Konstanz, Germany 

2004-2006  Marie-Curie Intra European fellowship at University of Graz, Austria

2006-2007  Marie Curie Reintegration Grant at JSI, Ljubljana, Slovenia

2006-2015  Senior Researcher: Department of Theoretical Physics,

                           Jo?ef Stefan Institute, Ljubljana, Slovenia

2008-2015  Senior Research Associate: Department of Chemistry,

                           University of Cambridge, UK

2014-2016  Assistant Director, PI & Manager of International Cooperation:

                            International Center for Soft Matter Research, BUCT, Beijing, China

2016-2020  (part time): ITN coordinator, Department of Chemistry,

                           University of Cambridge, UK

2016-2017  Associate Professor, Institute of Physics, Chinese Academy of Sciences

2017-20xx  Full Professor, IoP, Chinese Academy of Sciences, Beijing, China

RESEARCH INTERESTS

Colloidal interactions

-        charged colloids

-        magnetic colloids

-        polymer-nanoparticle mixtures

-        DNA-coated colloids

-        complex and many-body effects

Dynamic Self-Assembly

-        pattern formation

-        self-assembled structures and their macroscopic properties

-        nonequilibrium dynamics and transport in thermodynamic gradients

Multivalent binding

-        cell targeting

-        receptor activation

-        molecular recognition

Bacterial motility, active matter, physics of bacterial populations

-        chemotaxis

-        twitching motility

-        biofilm formation

-        active colloids

 



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