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学术报告:Physical virology:viruses and macromolecular interactions

日期: 2017-11-08     阅读次数:11

报告题目:Physical virology:viruses and macromolecular interactions

报 告 人:Rudolf Podgornik, Chair Professor at University of Chinese Academy of Science

报告时间:1113日上午1010

报告地点:物理科技楼245

报告摘要:I will summarize some aspects of macromolecular interactions in the context of viruses, concentrating mostly on electrostatic interactions. I will present several models of the effects of electrostatic interactions on viruses. Starting from a discussion of charge distribution and the pertaining charge regulation description, I will explore in detail several examples of the role of charge-charge interactions for capsid stability as well as the interactions between the capsid proteins and the compactified genetic cargo. A simplified bu t, within well defined limitations, reliable approach can be used to derive expressions for electrostatic energies and the corresponding osmotic pressures in singlestranded RNA viruses and double-stranded DNA bacteriophages. The two types of viruses differ crucially in the spatial distribution of their genome charge which leads to essential differences in their free energies, depending on the capsid size and total charge in a quite different fashion. Differences in the free energies are trailed by the corresponding characteristics and variations in the osmotic pressure between the inside of the virus and the external bathing solution.

- M. Hernando-Pérez, A. X. Cartagena-Rivera, A. Lo?dorfer Bo?i?, P. J. P. Carrillo,

C. San Martín, M. G. Mateu, A. Raman, R. Podgornik and P. J. de Pablo,

Quantitative nanoscale electrostatics of viruses, Nanoscale, (2015) 7,

17289-17298.

- R. Podgornik, A. Aksoyoglu, S. Yasar, D. Svensek, V.A. Parsegian, DNA

Equation of State: In Vitro vs. In Viro, J. Phys. Chem. B, 120(26) 6051-6060

(2016) .

- H.R. Shojaei, A. Losdorfer Bozic, M. Muthukumar, and R. Podgornik, Effects of

long-range interactions on curvature energies of viral shells, Phys. Rev. E 93,

052415 (2016).

- Gonca Erdemci-Tandogan, Jef Wagner, Paul van der Schoot, Rudolf Podgornik,

and Roya Zandi, Effects of RNA branching on the electrostatic stabilization of

viruses, PHYSICAL REVIEW E 94, 022408 (2016).

报告人简介:

PROFESSIONAL EXPERIENCE

1977-1982 Research Assistant, Institute of Biophysics, Medical Faculty, Ljubljana, SLO.

1983-1986 Research Assistant, Institute Jozef Stefan, Ljubljana, Slovenia.

1986-1987 Staff Member, J. Stefan Institute, Ljubljana, SLO.

1987-1989 Postdoctoral fellow with V.A. Parsegian, Laboratory of Molecular Forces and

Assembly, National Institutes of Health, Bethesda, Maryland 20892, USA

1990-1992 Senior Staff Member, J. Stefan Institute, Ljubljana, SLO.

1992-1993 Postdoctoral fellow with B. Jonsson, Division of Physical Chemistry II,

University of Lund, Lund S - 22100, Sweden.

1993-1995 Visiting Scientist, Laboratory of Structural Biology, DCRT, National Institutes of

Health, Bethesda, Maryland 20892, USA.

1995-1998 Assistant Professor, Dept. of Physics, University of Ljubljana, SLO

1998-2010 Adjunct Research Scientist, Laboratory of Physical and Structural Biology,

National Institute of Child Health and Human Developement, National Institutes of Health,

Bethesda, Maryland 20892-5626, USA.

1998-2001 Associate Professor of Physics, Dept. of Physics, Faculty of Mathematics and

Physics, University of Ljubljana, SLO

2001- Full professor of physics, Dept. of Physics, Faculty of Mathematics and

Physics, University of Ljubljana, SLO

2008- Full professor of biophysics, School of medicine, University of Ljubljana, SLO

2010-2016 Adjunct Professor, Department of Physics, University of Massachusetts,

Amherst, USA

2013-2016 Adjunct Professor, Materials Science & Engineering Department at the Case

Western Reserve University, Cleveland, USA

2017- Chair Professor, University of Chinese Academy of Sciences, Beijing, CHINA

RESEARCH INTERESTS

- Macromolecular interactions

- Theory of electrostatic interactions in soft matter

- Macroscopic theory of van der Waals interactions

- Physics of DNA and RNA

- Fundamental polymer theory

- Physics of viruses

- Macromolecular simulations

- Fluctuation hydrodynamics

Papers: ~250 papers in refereed journals

Editor:

1. Coeditor-in-chief of the Journal of Biological Physics, published by Springer

2. Member of the Editorial board of the journal Scientific Reports published by Nature-Springer

3. Editorial Advisor of BMC Biophysics, an open access journal published by BioMed Central

3. Advisory Editor of the European Biophysics Journal (EBJ) published by Springer Nature on

behalf of the European Biophysical Societies Association (EBSA).

Membership: In 2013 and 2015 I have been a member of the Starting Grant Panel of the

European Research Council (ERC) for condensed matter physics.



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